Development of a validated UPLC–qTOF-MS/MS method for determination of bioactive constituent from Glycyrrhiza glabra
Identifieur interne : 000B08 ( Main/Exploration ); précédent : 000B07; suivant : 000B09Development of a validated UPLC–qTOF-MS/MS method for determination of bioactive constituent from Glycyrrhiza glabra
Auteurs : D. K. Gupta [Inde] ; M. K. Verma [Inde] ; R. Anand [Inde] ; R. K. Khajuria [Inde]Source :
- Journal of Pharmaceutical Analysis [ 2095-1779 ] ; 2013.
Abstract
An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–qTOF-MS/MS) method was developed and validated for the simultaneous determination of glycyrrhizin and glycyrrhetic acid. These analytes were separated on a reverse phase C18 column using a mobile phase of acetonitrile:2% acetic acid in water (75:25, v/v) with a flow rate of 200 μL/min. The qTOF-MS was operated under multiple reaction monitoring (MRM) mode using the electrospray ionization (ESI) technique with positive ion polarity. A comparison of three different extraction techniques i.e. accelerated solvent extraction (ASE), extraction under ultrasonic waves (USW) and the classical extraction by percolation (CE) method was done and quantification of these extracts was also carried out by the proposed method.
Url:
DOI: 10.1016/j.jpha.2013.01.001
PubMed: 29403818
PubMed Central: 5760977
Affiliations:
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K." last="Gupta">D. K. Gupta</name><affiliation wicri:level="1"><nlm:aff id="aff1">Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001</wicri:regionArea><wicri:noRegion>Jammu 180001</wicri:noRegion></affiliation></author><author><name sortKey="Verma, M K" sort="Verma, M K" uniqKey="Verma M" first="M. K." last="Verma">M. K. Verma</name><affiliation wicri:level="1"><nlm:aff id="aff2">Analytical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Analytical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001</wicri:regionArea><wicri:noRegion>Jammu 180001</wicri:noRegion></affiliation></author><author><name sortKey="Anand, R" sort="Anand, R" uniqKey="Anand R" first="R." last="Anand">R. Anand</name><affiliation wicri:level="1"><nlm:aff id="aff2">Analytical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Analytical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001</wicri:regionArea><wicri:noRegion>Jammu 180001</wicri:noRegion></affiliation></author><author><name sortKey="Khajuria, R K" sort="Khajuria, R K" uniqKey="Khajuria R" first="R. K." last="Khajuria">R. K. Khajuria</name><affiliation wicri:level="1"><nlm:aff id="aff2">Analytical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Analytical Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001</wicri:regionArea><wicri:noRegion>Jammu 180001</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Pharmaceutical Analysis</title><idno type="ISSN">2095-1779</idno><idno type="eISSN">2214-0883</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC–qTOF-MS/MS) method was developed and validated for the simultaneous determination of glycyrrhizin and glycyrrhetic acid. These analytes were separated on a reverse phase C18 column using a mobile phase of acetonitrile:2% acetic acid in water (75:25, v/v) with a flow rate of 200 μL/min. The qTOF-MS was operated under multiple reaction monitoring (MRM) mode using the electrospray ionization (ESI) technique with positive ion polarity. A comparison of three different extraction techniques i.e. accelerated solvent extraction (ASE), extraction under ultrasonic waves (USW) and the classical extraction by percolation (CE) method was done and quantification of these extracts was also carried out by the proposed method.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Rossum, T G" uniqKey="Van Rossum T">T.G. Van Rossum</name></author><author><name sortKey="Vulto, A G" uniqKey="Vulto A">A.G. Vulto</name></author><author><name sortKey="Demon, R A" uniqKey="Demon R">R.A. 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Tan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Gupta, D K" sort="Gupta, D K" uniqKey="Gupta D" first="D. K." last="Gupta">D. K. Gupta</name></noRegion><name sortKey="Anand, R" sort="Anand, R" uniqKey="Anand R" first="R." last="Anand">R. Anand</name><name sortKey="Khajuria, R K" sort="Khajuria, R K" uniqKey="Khajuria R" first="R. K." last="Khajuria">R. K. Khajuria</name><name sortKey="Verma, M K" sort="Verma, M K" uniqKey="Verma M" first="M. K." last="Verma">M. K. Verma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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